यूकेरियोटिक 80S राइबोसोम की संरचनात्मक संरचना में, निम्नलिखित में से कौन से घटक देखे जा सकते हैं? (A) बड़ी उप-इकाई (60S) में 28S rRNA, 5.8S rRNA और 5S rRNA (B) छोटी उप-इकाई (40S) में 18S rRNA और लगभग 33 प्रोटीन (C) 23S rRNA (D) बड़ी उप-इकाई (60S) में लगभग 46-49 प्रोटीन नीचे दिए गए विकल्पों में से सही उत्तर चुनिए:

Arrange the following events in the correct chronological order during receptor-mediated endocytosis of LDL and its subsequent intracellular fate: A. LDL binds to the LDL receptor in a clathrin-coated pit at the plasma membrane B. Dynamin oligomerises at the neck of the coated pit and hydrolyses GTP to pinch off the vesicle C. Clathrin triskelions are recruited via AP-2 adaptor binding to the NPXY internalisation signal of the LDL receptor D. Acidification of the early endosome (pH ~6) causes dissociation of LDL from its receptor E. LDL receptor is recycled to the plasma membrane via Rab11-positive recycling endosomes F. Cholesterol esters are hydrolysed by lysosomal acid lipase after late endosome–lysosome fusion

A researcher treats cultured mammalian cells with Brefeldin A (BFA) for 30 minutes and then labels newly synthesised proteins with 35S-methionine. She finds that: - Labelled proteins accumulate in the ER. - The cis-Golgi marker GM130 redistributes to the ER. - Lysosomal enzyme precursors (bearing mannose-6-phosphate) are secreted into the medium instead of reaching lysosomes. Which of the following mechanistic statements best explains all three observations?