Science and Technology · Genomics & Gene Editing

With reference to emerging genome-editing technologies, consider the following statements: I. Nonsense mutations can generate premature termination codons that interrupt normal protein synthesis. II. Prime editing is a CRISPR-based genome editing approach that can function without introducing double-strand breaks in DNA. III. Transfer RNA (tRNA) plays a role in translation by carrying specific amino acids to the ribosome during protein synthesis. IV. All gene-editing therapies necessarily involve direct correction of the original disease-causing mutation within the genome. How many of the statements given above are correct?