Physics · Organic Stereochemistry
Which stereochemical model best explains the nucleophilic addition of a Grignard reagent (such as i-PrMgBr) to an α-chiral ketone possessing a Lewis-basic nitrogen substituent (like -NMePh), leading to chelation control?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Felkin-Anh Model
- 2Cram open-chain model
- 3Cram chelation model✓
- 4Cornforth model
Correct answer
Cram chelation model
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