Science · Analgesics and Pharmacokinetics
Which statement is correct regarding the absorption and pharmacokinetics of paracetamol (acetaminophen)?
- 1Its clearance is significantly prolonged in uncomplicated mild renal failure
- 2It directly antagonizes the uricosuric action of probenecid
- 3More than 30% of the dose is excreted unchanged in the urine
- 4Its rate of absorption is directly dependent on the rate of gastric emptying✓
Correct answer
Its rate of absorption is directly dependent on the rate of gastric emptying
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