Pharmacy · Pharmaceutical Chemistry
Which statement best describes the mechanism of specific acid catalysis during ester hydrolysis?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1A proton transfers to the carbonyl oxygen, increasing carbonyl electrophilicity and accelerating nucleophilic attack.✓
- 2The acid abstracts an electron from water, forming a hydroxyl free radical.
- 3The acid donates an electron pair to the carbonyl oxygen, deactivating it toward nucleophiles.
- 4The acid removes a proton from the alkyl group, decreasing overall reaction velocity.
Correct answer
A proton transfers to the carbonyl oxygen, increasing carbonyl electrophilicity and accelerating nucleophilic attack.
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