Biology · Bioinformatics
Which of the following statements is TRUE regarding gene prediction methodologies?
- 1They rely entirely on empirical laboratory transcriptomics alone without computational modeling.
- 2An ab initio-based approach predicts gene structures using statistical features of the genomic sequence alone.✓
- 3An ab initio-based approach identifies genes primarily by computing direct similarity with known homologous proteins.
- 4Computational gene prediction is impossible for newly sequenced eukaryotic genomes.
Correct answer
An ab initio-based approach predicts gene structures using statistical features of the genomic sequence alone.
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