Biology · Nobel Prize in Medicine 2023
When dendritic cells recognize unmodified in vitro transcribed synthetic mRNA as a foreign substance, what immediate physiological response occurs?
- 1Immediate cellular lysis via the activation of the complement membrane attack complex.
- 2Upregulation of histone acetylation causing rapid global gene silencing.
- 3Secretory cell apoptosis mediated through the immediate downregulation of p53 pathways.
- 4Activation of the cells leading to the release of inflammatory signaling molecules like interferon-alpha.✓
Correct answer
Activation of the cells leading to the release of inflammatory signaling molecules like interferon-alpha.
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