Biology · Nobel Prize in Medicine 2023
What biochemical difference explains why synthetic in vitro transcribed mRNA triggers an inflammatory response in mammalian cells while native mammalian cell mRNA does not?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Mammalian cell mRNA utilizes an entirely unique set of four nitrogenous bases compared to synthetic variants.
- 2Synthetic mRNA lacks a poly-A tail, preventing it from binding to protective cytoplasmic proteins.
- 3Mammalian cell mRNA contains naturally occurring chemical base modifications, whereas unmodified synthetic mRNA lacks them.✓
- 4Synthetic mRNA forms stable double-stranded structures that cannot be uncoiled by helicases.
Correct answer
Mammalian cell mRNA contains naturally occurring chemical base modifications, whereas unmodified synthetic mRNA lacks them.
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