Biology · Cell Biology

Thousands of proteins that are synthesized in the cytoplasm are imported into the nucleus through the nuclear pore complex (NPC) every minute. These proteins contain a Nuclear Localization Signal (NLS) that directs their selective transport into the nucleus. This nuclear import requires: A. A small monomeric G-protein Ran. B. A nuclear transport receptor that interacts with the NLS on a cargo protein. C. A GTPase activating protein (GAP) bound to the chromatin tethered to the nuclear membrane. D. A Guanine Exchange Factor (GEF) bound to the chromatin inside the nucleus. Which one of the following options represents all correct statements?