Biology · Cell Biology
The Ran GTPase imposes directionality on transport through nuclear pore complexes (NPCs). Like other GTPases, Ran is a molecular switch that can exist in two conformational states, depending on whether bound to GDP or GTP. Possible reasons for compartmentalization of Ran-GTP accumulation are: A. Ran-GAP is enriched in the nucleus B. Ran-GAP is localized in the cytosol C. Ran-GEF is enriched in the nucleus D. The nuclear import receptors help in the compartmentalization of Ran-GTP Which of the options below has all the correct statements about Ran-GTP compartmentalization?
- 1C and D
- 2B and C✓
- 3A and B
- 4A only
Correct answer
B and C
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