Biology · Cancer Biology
The gradient of oxygen available to cells at inner regions of a tumor tissue environment is typically low, which creates a hypoxic microenvironment. If enough oxygen is supplied to the cancer cells residing in this hypoxic microenvironment, which one of the following processes may NOT occur?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Lactate generation in the tumor microenvironment, which contributed to M2 polarization of tissue-associated macrophages, will continue at the same rate.✓
- 2Expression of HIF-1α dependent genes will be lowered.
- 3The Warburg effect will be suppressed and oxidative phosphorylation will increase as sufficient oxygen becomes available.
- 4HIF-1α, which is stable under hypoxic conditions, may undergo oxygen-dependent hydroxylation, targeting it for ubiquitination and proteolysis by VHL.
Correct answer
Lactate generation in the tumor microenvironment, which contributed to M2 polarization of tissue-associated macrophages, will continue at the same rate.
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