Biology · Immunology
Strain A mice were crossed with strain B mice to obtain F1 generation mice, i.e., (A × B)F1. A scientist implanted thymectomized and irradiated (A × B)F1 mice with a B-type thymus, and then reconstituted the immune system with an intravenous infusion of (A × B)F1 bone marrow cells. These chimeric mice were infected with lymphocytic choriomeningitis virus (LCMV), and the spleen T cells were tested for their ability to kill LCMV-infected target cells from strain A or strain B mice. Which one of the following is the correct outcome?
- 1Neither cells from strain A nor from strain B will be killed
- 2LCMV-infected target cells from both strain A and B will be killed
- 3LCMV-infected target cells from strain B only will be killed✓
- 4LCMV-infected target cells from strain A only will be killed
Correct answer
LCMV-infected target cells from strain B only will be killed
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