Biology · Developmental Biology
Sonic hedgehog (Shh) specifies the anterior-posterior axis during limb development. Which one of the following statements regarding it is correct?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Specification of the digit is primarily dependent on the amount of time the Shh gene is expressed and to a small extent on the concentration of the Shh protein that other cells receive.✓
- 2When the genes for Shh and Gli3 are conditionally knocked out in the mouse limb, the resulting limbs do not form any digits.
- 3Descendants of Shh secreting cells become the bone and muscle of the anterior limb.
- 4Shh secreting cells undergo apoptosis after performing their function.
Correct answer
Specification of the digit is primarily dependent on the amount of time the Shh gene is expressed and to a small extent on the concentration of the Shh protein that other cells receive.
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