Biology · Cancer Biology and Cell Signaling

Signalling pathways that are important for tumorigenesis and cancer include those involved in cell proliferation and cell growth. The following statements were made regarding pathways and molecules involved in cancer: A. Abnormal activation of the PI3-kinase/Akt pathway is involved in dysregulated growth. B. Bcl2 overexpression and enhanced apoptosis lead to efficient clearance of damaged cancer cells. C. Loss of p53 can allow cells with damaged DNA to escape apoptosis and continue to proliferate. D. Inhibition of the Rho family GTPase RhoC leads to enhanced actin-based cell motility and facilitates metastasis. Which one of the following options represents the combination of all correct statements?