Biology · Cell Biology

Proteins possess a sorting signal known as a nuclear localization signal (NLS) for their import into the nucleus. Consider the following statements regarding the import of proteins destined for the nucleus: A. The nuclear import receptor (importin) binds to the nuclear localization signal of the cargo protein. B. The import receptor contains several low-affinity binding sites for the FG-repeats of nucleoporins. C. The nuclear import receptor-cargo complex is dissociated by RanGDP in the nucleus. D. The nuclear import receptor-cargo complex binds to RanGTP in the cytosol and traverses the nuclear envelope. Which one of the following options contains all the correct statements about nuclear protein import?