Biology · Human Health and Diseases
Match each lysosomal storage disease in Column I with its corresponding enzymatic deficiency and accumulating substrate in Column II: Column I A. Gaucher disease (Type I) B. Tay-Sachs disease C. Niemann-Pick disease (Type A/B) D. I-cell disease (Mucolipidosis II) Column II1. Hexosaminidase A deficiency; accumulation of GM2 ganglioside in neurons2. β-glucocerebrosidase deficiency; accumulation of glucocerebroside in macrophages3. Sphingomyelinase deficiency; accumulation of sphingomyelin in liver, spleen, and brain4. GlcNAc-1-phosphotransferase deficiency; failure of M6P tagging causing secretion of enzymes into plasma
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1A-2, B-1, C-3, D-4✓
- 2A-1, B-2, C-4, D-3
- 3A-2, B-3, C-1, D-4
- 4A-3, B-1, C-2, D-4
Correct answer
A-2, B-1, C-3, D-4
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