Biology · Cell Biology & Protein Targeting
Match Column I (Signal / Sequence / Modification) with Column II (Targeting Destination & Recognition Machinery): Column I A. -KDEL (C-terminal tetrapeptide) B. -SKL (C-terminal tripeptide, PTS1) C. N-terminal amphipathic α-helix (MTS) D. Mannose-6-phosphate (M6P) on N-glycan Column II1. Peroxisome matrix; recognised by cytosolic Pex5 receptor2. ER lumen retention; recognised by KDEL receptor (Erd2p) in Golgi — retrieved via COPI vesicles3. Lysosome targeting; recognised by M6P receptor at TGN4. Mitochondrial matrix; recognised by Tom20/Tom22 of TOM complex, cleaved by MPP
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1A-2, B-1, C-4, D-3✓
- 2A-1, B-2, C-3, D-4
- 3A-2, B-4, C-1, D-3
- 4A-3, B-1, C-4, D-2
Correct answer
A-2, B-1, C-4, D-3
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