Biology · Molecular Biology
Many organisms encode only 18 aminoacyl-tRNA synthetases (aaRS), lacking the specific enzymes required for the direct aminoacylation of tRNAAsn and tRNAGln with asparagine (Asn) and glutamine (Gln), respectively. Which of the following mechanisms correctly explains how these organisms synthesize proteins containing Asn and Gln?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1The organisms lack Asn and Gln entirely within their proteome.
- 2Selected Asp and Glu residues are post-translationally modified directly within the polypeptide chain.
- 3The tRNAAsn and tRNAGln are first misaminoacylated with Asp and Glu by AspRS and GluRS, respectively, and then modified to Asn and Gln while attached to the tRNAs.✓
- 4Precursors of mRNAs encoding AspRS and GluRS undergo alternative splicing to generate functional AsnRS and GlnRS.
Correct answer
The tRNAAsn and tRNAGln are first misaminoacylated with Asp and Glu by AspRS and GluRS, respectively, and then modified to Asn and Gln while attached to the tRNAs.
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