Localized increases in the cytosolic level of free Ca2+ are critical to its function as a second messenger. Calmodulin, a small cytosolic protein, mediates many cellular effects of Ca2+. Which of the following is NOT CORRECT for the Ca2+-calmodulin interaction?

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Biology · Cell Signaling

Verified Solution4 OptionsUpdated: October 2026👁️1 View

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Each calmodulin molecule binds six Ca2+ ions in a cooperative fashion.

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Answer 1

Each calmodulin molecule binds six Ca2+ ions in a cooperative fashion.

Answer 2

Binding of Ca2+ causes calmodulin to undergo a conformational change leading to active calmodulin.

Answer 3

Since binding of Ca2+ is cooperativ e, a small change in the level of cytosolic Ca leads to a large change in the level of active calmodulin.

Answer 4

One of the many enzymes activated by Ca2+-calmodulin is cAMP phosphodiesterase, which degrades cAMP and links Ca and cAMP signaling.

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