Biology · Animal Physiology
In yeast, under anaerobic conditions, pyruvate is fermented to ethanol. The mammalian liver also expresses alcohol dehydrogenase (Liver ADH : L-ADH). Choose the option that best explains the physiological significance of L-ADH in the mammalian liver in the absence of ethanol fermentation.
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Mammalian L-ADH primarily performs non-metabolic moonlighting functions.
- 2Mammalian L-ADH converts pyruvate to lactate and the NAD+ thus generated drives glycolysis.
- 3NAD+ produced by L-ADH drives glycolysis in the liver.
- 4The direction of the L-ADH reaction varies with the relative concentrations of acetaldehyde and ethanol. In addition, the enzyme metabolizes alcohols produced anaerobically by intestinal microflora.✓
Correct answer
The direction of the L-ADH reaction varies with the relative concentrations of acetaldehyde and ethanol. In addition, the enzyme metabolizes alcohols produced anaerobically by intestinal microflora.
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