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In the paragraph below, choose the correct blank where the given sentence fits best. Sentence: 'Its effects also extend to an increased risk of cataracts, weakened immune function, and reduced fertility in both men and women.' Paragraph: The adverse effects of smoking on human health are well-documented and far-reaching. The toxic chemicals in cigarette smoke damage the airways and air sacs in the lungs, leading to conditions like chronic bronchitis and emphysema. (1) ____ Beyond the respiratory system, smoking significantly elevates the risk of heart disease and stroke by causing arterial damage and increasing blood pressure. (2) ____ These cardiovascular effects are a major cause of preventable death worldwide. (3) ____ The cumulative damage from years of smoking can affect nearly every organ in the body. (4) ____