Physics · Biology
In the context of cellular senescence and replicative ageing in biological sciences, the term 'Hayflick limit' is best described as:
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- 1The threshold number of cumulative genetic mutations a somatic cell can tolerate before undergoing apoptosis.
- 2The finite number of times a normal human somatic cell can undergo mitotic division under in-vitro conditions before entering irreversible growth arrest.✓
- 3The upper bound of self-renewal cycles that pluripotent stem cells can complete prior to terminal differentiation.
- 4The maximum duration for which isolated human cells can remain metabolically active in artificial culture environments.
Correct answer
The finite number of times a normal human somatic cell can undergo mitotic division under in-vitro conditions before entering irreversible growth arrest.
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