Chemistry · Asymmetric Synthesis
In a stereoselective asymmetric aldol reaction governed by the Zimmerman-Traxler transition state, the absolute stereochemical outcome is determined by the facial selectivity. The key aldol reaction leading to the major enantiomer involves the attack of the:
- 1Re face of enolate onto the Si face of aldehyde✓
- 2Re face of enolate onto the Re face of aldehyde
- 3Si face of enolate onto the Si face of aldehyde
- 4Si face of enolate onto the Re face of aldehyde
Correct answer
Re face of enolate onto the Si face of aldehyde
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