Biology · Molecular Biology
In a bacterial stress response, cells synthesize a group of chaperone proteins called heat shock proteins, such as DnaK, DnaJ, GroEL, GroES, and GrpE. DnaK is an ATP-binding protein that binds to the newly synthesized polypeptide in conjunction with DnaJ. Which one of the following statements correctly states a step in the subsequent process of protein folding?
- 1ATP hydrolysis is required for the phosphorylation of GrpE
- 2ATP hydrolysis is required for the direct phosphorylation of DnaJ
- 3DnaJ acts as a nucleotide exchange factor that replaces ADP with ATP in DnaK
- 4The affinity of DnaK for the polypeptide increases upon hydrolysis of ATP to ADP✓
Correct answer
The affinity of DnaK for the polypeptide increases upon hydrolysis of ATP to ADP
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