Pharmacy · Medicinal Chemistry
In a bacterial infection producing aminoglycoside acetyltransferase enzymes, which aminoglycoside typically retains efficacy and why?
- 1Streptomycin, due to the absence of a 2-deoxystreptamine ring
- 2Amikacin, due to steric hindrance from its L-hydroxyaminobutyryl side chain at N-1✓
- 3Gentamicin, because it lacks amino groups
- 4Neomycin, due to its high polarity
Correct answer
Amikacin, due to steric hindrance from its L-hydroxyaminobutyryl side chain at N-1
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