Biology · Immunology
Following are the statements which explain why patients with X-linked hyper-IgM syndrome express normal genes for other antibody subtypes but fail to produce IgG, IgA, or IgE: A. CD40L expressed on T cells is defective. B. CD40L mediates binding of T-cells to B-cells and sends co-stimulatory signals to the B-cells for class switching. C. Without CD40 on macrophages, class switching does not occur. D. CD40L mediates binding of B-cells to macrophages and sends co-stimulatory signals to the B-cells for class switching. Select the option with the correct combination of statements.
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1A and D
- 2A and B✓
- 3A, B and C
- 4A, C and D
Correct answer
A and B
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