Biology · Developmental Biology and Genetics
ENZ function prevents premature differentiation of mouse neural stem cells. Kinase inhibitor treatment differentiates these cells prematurely. This is prevented if a specific serine-to-aspartate (S to D) mutation is introduced in ENZ. Based on this information, which one of the following statements is INCORRECT?
- 1The specific serine to aspartate substitution has the same effect as phosphorylation of ENZ on neural stem cell differentiation.
- 2The specific serine may be the site of ENZ phosphorylation.
- 3The serine-to-aspartate mutation is expected to yield the same results as an asparagine substitution.✓
- 4The serine-to-aspartate mutation is expected to yield the same results as a glutamic acid substitution.
Correct answer
The serine-to-aspartate mutation is expected to yield the same results as an asparagine substitution.
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