During the acylation step of chymotrypsin-catalyzed peptide hydrolysis, a tetrahedral intermediate is formed. The developing negative charge on the oxyanion oxygen is primarily stabilized by:

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Chemistry · Enzyme Mechanisms

Verified Solution4 OptionsUpdated: October 2026👁️1 View

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Hydrogen bonds formed by backbone NH groups of Gly193 and Ser195

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Asp102 via direct electrostatic interactions

Answer 2

His57 donating a proton to the oxyanion

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Hydrogen bonds formed by backbone NH groups of Gly193 and Ser195

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