Biology · Animal Physiology

During physical exercise, a large amount of oxygen is delivered to the active muscles by many physiological adjustments including a change in the P 50 value (which is determined by PO 2 at which hemoglobin is half-saturated with oxygen). The following proposed statements explain the mechanism of change in P 50 during exercise: A. P 50 is increased during exercise as the temperature rises in active muscles. B. During exercise, metabolites accumulate in the active muscles resulting in higher pH that increases P 50 . C. P 50 is increased during exercise as CO 2 is decreased in active muscles. D. An increase in 2,3-DPG has been reported in non-trained persons within 60 min of exercise resulting in higher P 50 . Which one of the following options represents the correct combination of the above statements?