Biology · Developmental Biology
During fertilization in mammals, the proteins Izumo and Juno are required for the recognition of sperm and egg. Izumo and Juno are found specifically on the sperm and egg, respectively. Which one of the following in vivo or cellular experiments best demonstrates that Izumo and Juno interact with each other to mediate adhesion?
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- 1Two independent non-germ cell lines (e.g., kidney cells) are developed, one expressing Izumo and the other Juno. When mixed, they aggregate with each other.✓
- 2If a CFP-fused Izumo protein is mixed with YFP-fused Juno protein in a tube, FRET occurs, showing energy transfer.
- 3Whole mount immunostaining for Izumo and Juno shows their presence on the sperm and egg, respectively.
- 4If sperms from a male mouse where Izumo has been knocked out are used to fertilize eggs from a normal female, no fertilization occurs.
Correct answer
Two independent non-germ cell lines (e.g., kidney cells) are developed, one expressing Izumo and the other Juno. When mixed, they aggregate with each other.
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