Science · Biology

Consider the following statements: Statement I: Conventional molecular dynamics simulations face difficulty in capturing rare molecular events such as ligand unbinding because these processes occur over long time scales. Statement II: Ligand residence time is an important pharmacokinetic parameter because it reflects how long a drug remains bound to its target, often correlating better with therapeutic efficacy than binding affinity alone. Statement III: Biased simulation techniques that apply artificial forces or elevated temperatures can distort the natural kinetic pathways of molecular interactions. Which one of the following is correct in respect of the above statements?