Biology · Human Diseases & Microbiome

Consider the following statements regarding ulcerative colitis and recent microbiome-based findings: I. Ulcerative colitis is a chronic inflammatory bowel disease primarily affecting the colon and rectum. II. Macrophages in the gut play a crucial role in maintaining immune balance by clearing microbes and cellular debris. III. Aerolysin, a toxin produced by certain bacteria, directly damages the gut epithelial lining before affecting immune cells. IV. Disruption of the gut microbiome can convert normally harmless microbes into disease-causing pathobionts. How many of the above statements are correct?