Biology · Human Health and Environment

Consider the following statements regarding the links discussed by medical researchers between PM2.5 pollution and rheumatoid arthritis (RA): I. PM2.5 particles are capable of entering the bloodstream and triggering systemic inflammatory responses. II. Consistent high pollution levels can induce inflammatory pathways related to autoimmune symptoms before clear clinical diagnoses emerge. III. Increased winter pollution levels have shown seasonal correlations with autoantibody flares in vulnerable populations. IV. Long-term exposure to PM2.5 leads to systemic oxidative stress, contributing to extra-articular manifestations affecting joints and other organs. How many of the above statements are correct?