Biology · Genetics & Neuromuscular Disorders

Consider the following statements regarding inherited peripheral neuropathies (IPN): I. Inherited peripheral neuropathies are genetic disorders that affect peripheral nerves and may lead to muscle weakness, sensory loss, and deformities. II. All mutations in genes coding for aminoacyl-tRNA synthetases (ARS) lead to peripheral neuropathy. III. Disease-causing mutations in ARS genes often show a dominant-negative effect, where the mutant protein interferes with the normal protein. IV. Peripheral neuropathy mutations generally enhance protein synthesis efficiency in cells. How many of the above statements are correct?