Biology · Molecular Biology

Consider bidirectional replication starting from an origin. If lagging strand synthesis produces short Okazaki fragments that require joining by DNA ligase, which of the following statements is correct regarding a ligase-deficient (lig-) mutant? A. On the right side of the replication origin, leading strand synthesis occurs using the upper strand as the template. B. On the right side of the replication origin, leading strand synthesis occurs using the lower strand as the template. C. A ligase-deficient (lig-) mutant would affect replication of the lower strand on the right side of the origin. D. A ligase-deficient (lig-) mutant would affect replication of the lower strand on the left side of the origin.