Biology · Metabolic Pathways and Regulation
Consider a branched metabolic pathway where precursor D converts to E, which then converts to F. F branches into two pathways: one leading to end-product K (via intermediate G) and another leading to end-product L (via intermediate H). Under which of the following conditions would stoichiometric amounts of end-products K and L be obtained if a concerted feedback inhibition mechanism were in operation?
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- 1K inhibits F → G and L inhibits F → H; D → E is inhibited only at equal accumulated amounts of K and L✓
- 2D → E is inhibited at equal amounts of K and L; K inhibits F → H and L inhibits F → G
- 3D → E is inhibited at equal amount of G and H; K inhibits F → H and L inhibits F → G
- 4K inhibits F → H and L inhibits F → G
Correct answer
K inhibits F → G and L inhibits F → H; D → E is inhibited only at equal accumulated amounts of K and L
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