Biology · Immunology
Bone marrow cells were sorted using 4 cell-surface markers: CD45R (B220), CD43 (leukosialin), membrane-associated Immunoglobulin M (mIgM), and membrane-associated Immunoglobulin D (mIgD). The sorted cells were analyzed for heavy chain immunoglobulin (Ig) gene rearrangements to categorize them into developmental stages. Consider the following observations and inferences: S.NoStatus of cell surface markersStatus of Ig heavy chain rearrangementInference drawnACD45R+, CD43-, mIgMhi, mIgDhiVHDJH-CμMature B cellBCD45R+, CD43+, mIgM-, mIgD-Germline arrangementPro-B cellCCD45R+, CD43+, mIgMlow, mIgD-VHDJH-CμLate stages of pre-B cell (small pre-B cell)DCD45R+, CD43+, mIgM-, mIgD-VHDJHImmature B cellECD45R-, CD43+, mIgM-, mIgD-Germline arrangementMay not be a precursor B cell Which of the above inferences are correct?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1B and D only
- 2A, B, C and E only
- 3A, B and E only✓
- 4B, D, and E only
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A, B and E only
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