Biology · Human Health and Diseases

Arrange the following biological events and clinical manifestations in the chronological progression of Cancer, starting from the cellular level to the advanced systemic stage: A. The local invasion of abnormal cells into nearby tissues B. The ultimate culmination into advanced symptoms, including severe organ dysfunction and extreme weight loss (cachexia) C. The initiation of the condition through the uncontrolled and abnormal growth of cells D. The systemic progression of the disease, defined by its spread to other organs (metastasis)