Biology · Immunology
A transgenic mouse was generated for both heavy and light chains specific for the MHC molecule H-2K m , so that all B cells in this mouse had BCRs specific only for H-2K m and made only anti-H-2K m specific antibodies. By appropriate breeding, the H-2K m specific immunoglobulin transgene was introduced into mice bearing different MHC genotypes: H-2K n and H-2K m/n . With respect to the selection of B-cells within the bone marrow of H-2K n and H-2K m/n mice, which of the following statements is correct?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1In H-2K n mice, the transgenic antibodies will not be detected on the surface of any of the B cells.
- 2In H-2K m/n mice, the transgenic antibodies will not be detected on the surface of any of the B cells.
- 3In H-2K n mice, the transgenic antibodies will be detected on the surface of some of the B cells but not released in the serum.
- 4In H-2K m/n mice, the transgenic antibodies will be detected on the surface of some of the B cells.✓
Correct answer
In H-2K m/n mice, the transgenic antibodies will be detected on the surface of some of the B cells.
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