Biology · Biomolecules
A synthetic nucleoside analog lacks antiviral activity despite its close structural similarity to natural nucleosides. Which of the following best explains this observation?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1The analog is completely incapable of forming glycosidic bonds.
- 2The analog lacks the 3'-OH group required for DNA chain elongation.
- 3The analog cannot undergo phosphorylation by cellular kinases to become active.✓
- 4The analog contains a purine base in place of a pyrimidine base.
Correct answer
The analog cannot undergo phosphorylation by cellular kinases to become active.
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