Biology · Locomotion and Movement
A physiologist applies a toxin to an isolated skeletal muscle preparation that blocks Ca2+ binding to troponin, but does not affect Ca2+ release from the sarcoplasmic reticulum. The muscle is then electrically stimulated. Which of the following observations is most likely?
- 1The muscle undergoes irreversible continuous contraction
- 2Myosin heads cannot hydrolyze ATP, so no power stroke occurs
- 3Ca2+ accumulates in the sarcoplasm, but no effective contraction occurs✓
- 4Normal cross-bridge cycling occurs, but relaxation is delayed
Correct answer
Ca2+ accumulates in the sarcoplasm, but no effective contraction occurs
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