A patient is administered aspirin to prevent platelet aggregation through the irreversible inhibition of cyclooxygenase (COX). After 72 hours, the drug is withdrawn. Which observation best explains why antiplatelet effects persist beyond drug clearance?

Question

Biology · Pharmacology & Platelet Physiology

Verified Solution4 OptionsUpdated: October 2026👁️1 View

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Correct answer

Platelets are anucleate and cannot synthesise new COX protein; new platelets must be produced

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Answer 1

COX is regenerated slowly because it requires a prosthetic group derived from vitamin K

Answer 2

Aspirin induces feedback inhibition of thromboxane synthase for several days

Answer 3

Platelets are anucleate and cannot synthesise new COX protein; new platelets must be produced

Answer 4

Aspirin has a very long plasma half-life and continues to inhibit COX in plasma

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