Biology · Human Physiology and Pathology
A patient exhibits severe muscle fatigue during fasting despite normal glycogen stores. Biochemical analysis reveals defective transport of long-chain fatty acids into mitochondria. Which metabolic consequence best explains these symptoms?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1Increased glycolysis compensates fully for the ATP deficit
- 2Accumulation of cytosolic fatty acids due to the inability to generate acetyl-CoA via β-oxidation✓
- 3Conversion of fatty acids into glucose via gluconeogenesis in muscle tissue
- 4Enhanced ketone body utilization directly in muscle mitochondria independent of fatty acid entry
Correct answer
Accumulation of cytosolic fatty acids due to the inability to generate acetyl-CoA via β-oxidation
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