Biology · Developmental Biology
A network of genes regulates vertebrate eye development. The loss or gain of function of select genes are listed in Column X, and their effects or phenotypes are listed in Column Y. Column X: A. Loss of function of Shh B. Elevated levels of Shh in the prechordal plate C. Loss of function of Otx2 D. Loss of function of Mitf Column Y: (i) No eyes (ii) Disruption of anterior neural tube specification (iii) Defective pigmented retina (iv) Failure to split the eye field to form bilateral eye fields Which one of the following options represents all correct matches between column X and column Y?
- 1A - iv, B - i, C - ii, D - iii✓
- 2A - ii, B - iii, C - i, D - iv
- 3A - iii, B - ii, C - iv, D - i
- 4A - iv, B - ii, C - i, D - iii
Correct answer
A - iv, B - i, C - ii, D - iii
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