Biology · Cell Signaling
A cell is stimulated simultaneously by a GPCR activating the IP3/DAG pathway and a ligand activating an RTK. Which cellular outcome is most likely due to signal cross-talk?
- 1DAG production prevents Ras activation downstream of the RTK
- 2cAMP completely inhibits all RTK-mediated intracellular pathways
- 3IP3 directly phosphorylates RTKs to amplify downstream signaling
- 4Increased Ca2+ release from the ER enhances PKC activation initiated by RTK signaling✓
Correct answer
Increased Ca2+ release from the ER enhances PKC activation initiated by RTK signaling
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