Biology · Cell Biology & Cytoskeleton
A cell biologist observes that nocodazole treatment fragments the Golgi into numerous small vesicles scattered throughout the cytoplasm, while taxol treatment also disrupts the compact Golgi ribbon but instead locks it into long tubular/extended structures. Which of the following explanations is most consistent with both observations?
- 1The effects are due to off-target actions on actin; nocodazole depolymerises actin and taxol cross-links actin filaments.
- 2Nocodazole blocks COPI vesicle formation causing Golgi fragmentation; taxol activates COPII export causing Golgi elongation.
- 3The pericentrosomal Golgi ribbon requires dynamic microtubules for positioning; nocodazole depolymerises MTs causing dispersal, while taxol stabilises MTs but prevents the dynamic instability needed for Golgi ribbon compaction, trapping Golgi on stable MT tracks in extended form.✓
- 4Both drugs disrupt dynein motor function; nocodazole inhibits dynein processivity and taxol causes dynein hyperactivation.
Correct answer
The pericentrosomal Golgi ribbon requires dynamic microtubules for positioning; nocodazole depolymerises MTs causing dispersal, while taxol stabilises MTs but prevents the dynamic instability needed for Golgi ribbon compaction, trapping Golgi on stable MT tracks in extended form.
Download Single Question PDF
Save this question and verified answer as a clean study sheet with live clickable link.
Share with Friends & Study Groups
Challenge your peer aspirants on WhatsApp or Telegram to solve this question!
Preparing for Biology?
Practice full-length mock tests with real exam timers, instant score analysis, and all-India ranking.
Want more practice questions on Cell Biology & Cytoskeleton?
Solve complete topic-wise tests with detailed solutions on GkGet.
Related Practice Questions
Recommended practice questions in Biology · Cell Biology & Cytoskeleton