Biology · Enzymology and Clinical Diagnostics
A 50-year-old male presents 36 hours after chest pain onset. Serum analysis shows LDH-1 > LDH-2, elevated CK-MB, and elevated serum troponin I. Which statement regarding Lactate Dehydrogenase (LDH) isoenzymes is MOST accurate?
Verified Solution4 OptionsUpdated: October 2026👁️1 View
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- 1LDH isoenzymes cannot be distinguished by electrophoresis as they catalyze different reactions
- 2LDH-5 (M4) elevation is pathognomonic of acute myocardial infarction
- 3The 'flipped' LDH pattern (LDH-1 > LDH-2) occurs because cardiac muscle is rich in H subunits✓
- 4LDH-1 (H4) is the predominant form in liver tissue and is elevated primarily in hepatocellular damage
Correct answer
The 'flipped' LDH pattern (LDH-1 > LDH-2) occurs because cardiac muscle is rich in H subunits
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