Mathematics · Biophysical Kinetics
A 20-bp GC-rich promoter undergoes a conformational transition between the B-form and Z-form of DNA involving bases 6 to 13 (8 bp), leaving 5 contiguous B-DNA bp on one side and 7 contiguous B-DNA bp on the other side. The B- to Z-DNA transition occurs with a half-life of 2 s, and Z- to B-DNA transition has a half-life of 6 s. If a transcription factor requires 10 contiguous B-DNA base pairs for binding, for how many seconds in a 20 s window can the transcription factor remain bound to the promoter, assuming steady-state conditions?
- 115 s
- 210 s
- 35 s✓
- 44 s
Correct answer
5 s
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