What hypothesis did Karikó and Weissman propose to explain why in vitro transcribed RNA triggered an unwanted inflammatory reaction when introduced to dendritic cells?

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Biology · Molecular Biology & Therapeutics

Verified Solution4 OptionsUpdated: October 2026👁️1 View

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The absence of naturally occurring altered or modified bases in the in vitro RNA recognized as foreign

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The structural modification of the cellular receptors causing a permanent immune alert

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The contamination of the transcription buffer with microbial proteins and heavy metals

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